Scientific Publications

Causal relationships between migraine and microstructural white matter: a Mendelian randomization study

Zhao L, Zhao W, International Headache Genetics Consortium, Cao J, Tu Y

J Headache Pain. 2023 Feb 16;24(1):10. PUBMED: 36793015 DOI: 10.1186/s10194-023-01550-z.

Migraine, chronic kidney disease and kidney function: observational and genetic analyses

Zhang W, Zhang L, Yang L, Xiao C, Wu X, Yan P, Cui H, Yang C, Zhu J, Wu X, Tang M, Wang Y, Chen L, Liu Y, Zou Y, Zhang L, Yang C, Yao Y, Li J, Liu Z, Zhang B, Jiang X, International Headache Genetics Consortium

Hum Genet. 2023 Aug;142(8):1185-200. PUBMED: 37306871 DOI: 10.1007/s00439-023-02575-9.

Cluster Headache Genomewide Association Study and Meta-Analysis Identifies Eight Loci and Implicates Smoking as Causal Risk Factor

Winsvold BS, Harder AVE, Ran C, Chalmer MA, Dalmasso MC, Ferkingstad E, Tripathi KP, Bacchelli E, Borte S, Fourier C, Petersen AS, Vijfhuizen LS, Magnusson SH, O'Connor E, Bjornsdottir G, Happola P, Wang YF, Callesen I, Kelderman T, Gallardo VJ, de Boer I, Olofsgard FJ, Heinze K, Lund N, Thomas LF, Hsu CL, Pirinen M, Hautakangas H, Ribases M, Guerzoni S, Sivakumar P, Yip J, Heinze A, Kucukali F, Ostrowski SR, Pedersen OB, Kristoffersen ES, Martinsen AE, Artigas MS, Lagrata S, Cainazzo MM, Adebimpe J, Quinn O, Gobel C, Cirkel A, Volk AE, Heilmann-Heimbach S, Skogholt AH, Gabrielsen ME, Wilbrink LA, Danno D, Mehta D, Guethbjartsson DF, Hunt All-In Headache TIHGCDGC, Rosendaal FR, Willems van Dijk K, Fronczek R, Wagner M, Scherer M, Gobel H, Sleegers K, Sveinsson OA, Pani L, Zoli M, Ramos-Quiroga JA, Dardiotis E, Steinberg A, Riedel-Heller S, Sjostrand C, Thorgeirsson TE, Stefansson H, Southgate L, Trembath RC, Vandrovcova J, Noordam R, Paemeleire K, Stefansson K, Fann CS, Waldenlind E, Tronvik E, Jensen RH, Chen SP, Houlden H, Terwindt GM, Kubisch C, Maestrini E, Vikelis M, Pozo-Rosich P, Belin AC, Matharu M, van den Maagdenberg A, Hansen TF, Ramirez A, Zwart JA, International Consortium for Cluster Headache Genetics

Ann Neurol. 2023 Oct;94(4):713-26. PUBMED: 37486023 DOI: 10.1002/ana.26743.

Migraine, inflammatory bowel disease and celiac disease: A Mendelian randomization study

Welander NZ, Rukh G, Rask-Andersen M, Harder AVE, International Headache Genetics Consortium, van den Maagdenberg A, Schioth HB, Mwinyi J

Headache. 2023 May;63(5):642-51. PUBMED: 36705326 DOI: 10.1111/head.14470.

Shared genetics and causal relationships between migraine and thyroid function traits

Tasnim S, Wilson SG, Walsh JP, Nyholt DR, International Headache Genetics Consortium

Cephalalgia. 2023 Feb;43(2):3331024221139253. PUBMED: 36739509 DOI: 10.1177/03331024221139253.

The shared genetic risk architecture of neurological and psychiatric disorders: a genome-wide analysis

Smeland OB, Kutrolli G, Bahrami S, Fominykh V, Parker N, Hindley GFL, Rodevand L, Jaholkowski P, Tesfaye M, Parekh P, Elvsashagen T, Grotzinger AD, International Multiple Sclerosis Genetics Consortium, International Headache Genetics Consortium, Steen NE, van der Meer D, O'Connell KS, Djurovic S, Dale AM, Shadrin AA, Frei O, Andreassen OA

medRxiv. 2023 Sep 26. PUBMED: 37503175 DOI: 10.1101/2023.07.21.23292993.

Cross-trait analyses identify shared genetics between migraine, headache, and glycemic traits, and a causal relationship with fasting proinsulin

Islam MR, International Headache Genetics Consortium, Nyholt DR

Hum Genet. 2023 Aug;142(8):1149-72. PUBMED: 36808568 DOI: 10.1007/s00439-023-02532-6.

A causal effects of gut microbiota in the development of migraine

He Q, Wang W, Xiong Y, Tao C, Ma L, Ma J, You C, International Headache Genetics Consortium

J Headache Pain. 2023 Jul 17;24(1):90. PUBMED: 37460956 DOI: 10.1186/s10194-023-01609-x.

Integrating eQTL and GWAS data characterises established and identifies novel migraine risk loci

Ghaffar A, International Headache Genetics Consortium, Nyholt DR

Hum Genet. 2023 Aug;142(8):1113-37. PUBMED: 37245199 DOI: 10.1007/s00439-023-02568-8.

Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity

Bakker MK, Kanning JP, Abraham G, Martinsen AE, Winsvold BS, Zwart JA, Bourcier R, Sawada T, Koido M, Kamatani Y, Morel S, Amouyel P, Debette S, Bijlenga P, Berrandou T, Ganesh SK, Bouatia-Naji N, Jones G, Bown M, Rinkel GJE, Veldink JH, Ruigrok YM, HUNT All-In Stroke, CADISP group, International Consortium for Blood Pressure, International Headache Genetics Consortium, International Stroke Genetics Consortium (ISGC) Intracranial Aneurysm Working Group

Stroke. 2023 Mar;54(3):810-8. PUBMED: 36655558 DOI: 10.1161/STROKEAHA.122.040715.

Genetic analyses identify pleiotropy and causality for blood proteins and highlight Wnt/beta-catenin signalling in migraine

Tanha HM, International Headache Genetics Consortium, Nyholt DR

Nat Commun. 2022 May 11;13(1):2593. PUBMED: 35546551 DOI: 10.1038/s41467-022-30184-z.

NCOR2 is a novel candidate gene for migraine-epilepsy phenotype

Nuottamo ME, Happola P, Artto V, Hautakangas H, Pirinen M, Hiekkalinna T, Ellonen P, Lepisto M, Hamalainen E, International Headache Genetics Consortium (IHGC), FinnGenConsortium; Siren A, Lehesjoki AE, Kallela M, Palotie A, Kaunisto MA, Wessman M

Cephalalgia. 2022 Jun;42(7):631-44. PUBMED: 35166138 DOI: 10.1177/03331024211068065.

Elucidating the relationship between migraine risk and brain structure using genetic data

Mitchell BL, Diaz-Torres S, Bivol S, Cuellar-Partida G, International Headache Genetics Consortium, Gerring ZF, Martin NG, Medland SE, Grasby KL, Nyholt DR, Renteria ME

Brain. 2022 Sep 14;145(9):3214-24. PUBMED: 35735024 DOI: 10.1093/brain/awac105.

Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

Hautakangas H, Winsvold BS, Ruotsalainen SE, Bjornsdottir G, Harder AVE, Kogelman LJA, Thomas LF, Noordam R, Benner C, Gormley P, Artto V, Banasik K, Bjornsdottir A, Boomsma DI, Brumpton BM, Burgdorf KS, Buring JE, Chalmer MA, de Boer I, Dichgans M, Erikstrup C, Farkkila M, Garbrielsen ME, Ghanbari M, Hagen K, Happola P, Hottenga JJ, Hrafnsdottir MG, Hveem K, Johnsen MB, Kahonen M, Kristoffersen ES, Kurth T, Lehtimaki T, Lighart L, Magnusson SH, Malik R, Pedersen OB, Pelzer N, Penninx B, Ran C, Ridker PM, Rosendaal FR, Sigurdardottir GR, Skogholt AH, Sveinsson OA, Thorgeirsson TE, Ullum H, Vijfhuizen LS, Widen E, van Dijk KW; International Headache Genetics Consortium; HUNT All-in Headache; Danish Blood Donor Study Genomic Cohort;, Aromaa A, Belin AC, Freilinger T, Ikram MA, Jarvelin MR, Raitakari OT, Terwindt GM, Kallela M, Wessman M, Olesen J, Chasman DI, Nyholt DR, Stefansson H, Stefansson K, van den Maagdenberg A, Hansen TF, Ripatti S, Zwart JA, Palotie A, Pirinen M

Nat Genet. 2022 Feb;54(2):152-60. PUBMED: 35115687 DOI: 10.1038/s41588-021-00990-0.

Polygenic risk provides biological validity for the ICHD-3 criteria among Finnish migraine families

Happola P, Gormley P, Nuottamo ME, Artto V, Sumelahti ML, Nissila M, Keski-Santti P, Ilmavirta M, Kaunisto MA, Hamalainen EI, Ripatti S, Pirinen M, Wessman M, Palotie A, Kallela M, International Headache Genetics Consortium

Cephalalgia. 2022 Apr;42(4-5):345-56. PUBMED: 34648375 DOI: 10.1177/03331024211045651.

Genetic overlap and causality between blood metabolites and migraine

Tanha HM, Sathyanarayanan A, International Headache Genetics Consortium, Nyholt DR

Am J Hum Genet. 2021 Nov 4;108(11):2086-98. PUBMED: 34644541 DOI: 10.1016/j.ajhg.2021.09.011.

Association and genetic overlap between clinical chemistry tests and migraine

Tanha HM, Martin NG, Whitfield JB, Nyholt DR, International Headache Genetics Consortium

Cephalalgia. 2021 Oct;41(11-12):1208-21. PUBMED: 34130515 DOI: 10.1177/03331024211018131.

Network-guided search for genetic heterogeneity between gene pairs

Gumpinger AC, Rieck B, Grimm DG, International Headache Genetics Consortium, Borgwardt K

Bioinformatics. 2021 Apr 9;37(1):57-65. PUBMED: 32573681 DOI: 10.1093/bioinformatics/btaa581.

Chronic migraine: Genetics or environment?

Chalmer MA, Rasmussen AH, International Headache Genetics Consortium, 23andMe Research Team, Kogelman LJA, Olesen J, Hansen TF

Eur J Neurol. 2021 May;28(5):1726-36. PUBMED: 33428804 DOI: 10.1111/ene.14724.

Habitual sleep disturbances and migraine: a Mendelian randomization study

Daghlas I, Vgontzas A, Guo Y, Chasman DI, International Headache Genetics Consortium, Saxena R

Ann Clin Transl Neurol. 2020 Dec;7(12):2370-80. PUBMED: 33125193 DOI: 10.1002/acn3.51228.

A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine

Yanjun Guo, Pamela M Rist, Iyas Daghlas, Franco Giulianini, International Headache Genetics Consortium; 23andMe Research Team; Tobias Kurth, Daniel I Chasman

Nat Commun. 2020 Jul 6;11(1):3368. PUBMED: 32632093 DOI: 10.1038/s41467-020-17002-0.

Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache

Katherine M Siewert, Derek Klarin, Scott M Damrauer, Kyong-Mi Chang, Philip S Tsao, Themistocles L Assimes, George Davey Smith, Benjamin F Voight; The International Headache Genetics Consortium

Int J Epidemiol. 2020 Jun 1;49(3):1022-1031. PUBMED: 32306029 DOI: 10.1093/ije/dyaa050.

Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease

Julien Bryois, Nathan G Skene, Thomas Folkmann Hansen, Lisette J A Kogelman, Hunna J Watson, Zijing Liu, Eating Disorders Working Group of the Psychiatric Genomics Consortium; International Headache Genetics Consortium; 23andMe Research Team; Leo Brueggeman, Gerome Breen, Cynthia M Bulik, Ernest Arenas, Jens Hjerling-Leffler, Patrick F Sullivan

Nat Genet. 2020 May;52(5):482-493. PUBMED: 32341526 DOI: 10.1038/s41588-020-0610-9. Epub 2020 Apr 27.

Shared Molecular Genetic Mechanisms Underlie Endometriosis and Migraine Comorbidity

Emmanuel O Adewuyi, Yadav Sapkota, International Endogene Consortium Iec, 23andMe Research Team, International Headache Genetics Consortium IHGC, Asa Auta, Kosuke Yoshihara, Mette Nyegaard, Lyn R Griffiths, Grant W Montgomery, Daniel I Chasman, Dale R Nyholt

Genes (Basel). 2020 Feb 29;11(3):268. PUBMED: 32121467 DOI: 10.3390/genes11030268.

Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent

Christopher Hübel, Héléna A Gaspar, Jonathan R I Coleman, Ken B Hanscombe, Kirstin Purves, Inga Prokopenko, Mariaelisa Graff, Julius S Ngwa, Tsegaselassie Workalemahu, ADHD Working Group of the Psychiatric Genomics Consortium; Meta-Analyses of Glucose and Insulin-related traits consortium (MAGIC); Autism Working Group of the Psychiatric Genomics Consortium; Bipolar Disorder Working Group of the Psychiatric Genomics Consortium; Eating Disorders Working Group of the Psychiatric Genomics Consortium; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; OCD & Tourette Syndrome Working Group of the Psychiatric Genomics Consortium; PTSD Working Group of the Psychiatric Genomics Consortium; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Sex Differences Cross Disorder Working Group of the Psychiatric Genomics Consortium; Substance Use Disorders Working Group of the Psychiatric Genomics Consortium; German Borderline Genomics Consortium; International Headache Genetics Consortium; Paul F O'Reilly, Cynthia M Bulik, Gerome Breen

Nat Commun. 2019 Dec 18;10(1):5765. PUBMED: 31852892 DOI: 10.1038/s41467-019-13544-0.

Migraine polygenic risk score associates with efficacy of migraine-specific drugs

Lisette J.A. Kogelman, Ann-Louise Esserlind, Anne Francke Christensen, Swapnil Awasthi, Stephan Ripke, Andres Ingason, Olafur B. Davidsson, Christian Erikstrup, Henrik Hjalgrim, Henrik Ullum, Jes Olesen, Thomas Folkmann Hansen, DBDS Genomic Consortium, The International Headache Genetics Consortium

Neurol Genet. 2019 Oct 24;5(6):e364. PUBMED: 31872049 DOI: 10.1212/NXG.0000000000000364. eCollection 2019 Dec.

Molecular genetic overlap between migraine and major depressive disorder

Yang Y, Zhao H, Boomsma DI, Ligthart L, Belin AC, Smith GD, Esko T, Freilinger TM, Hansen TF, Ikram MA, Kallela M, Kubisch C, Paraskevi C, Strachan DP, Wessman M; International Headache Genetics Consortium, van den Maagdenberg AMJM, Terwindt GM, Nyholt DR.

Eur J Hum Genet. 2018 Jul 11. PUBMED: 29995844  DOI: 10.1038/s41431-018-0150-2. [Epub ahead of print]

Analysis of shared heritability in common disorders of the brain

Brainstorm Consortium, Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, Lee PH, Turley P, Grenier-Boley B, Chouraki V, Kamatani Y, Berr C, Letenneur L, Hannequin D, Amouyel P, Boland A, Deleuze JF, Duron E, Vardarajan BN, Reitz C, Goate AM, Huentelman MJ, Kamboh MI, Larson EB, Rogaeva E, St George-Hyslop P, Hakonarson H, Kukull WA, Farrer LA, Barnes LL, Beach TG, Demirci FY, Head E, Hulette CM, Jicha GA, Kauwe JSK, Kaye JA, Leverenz JB, Levey AI, Lieberman AP, Pankratz VS, Poon WW, Quinn JF, Saykin AJ, Schneider LS, Smith AG, Sonnen JA, Stern RA, Van Deerlin VM, Van Eldik LJ, Harold D, Russo G, Rubinsztein DC, Bayer A, Tsolaki M, Proitsi P, Fox NC, Hampel H, Owen MJ, Mead S, Passmore P, Morgan K, Nöthen MM, Rossor M, Lupton MK, Hoffmann P, Kornhuber J, Lawlor B, McQuillin A, Al-Chalabi A, Bis JC, Ruiz A, Boada M, Seshadri S, Beiser A, Rice K, van der Lee SJ, De Jager PL, Geschwind DH, Riemenschneider M, Riedel-Heller S, Rotter JI, Ransmayr G, Hyman BT, Cruchaga C, Alegret M, Winsvold B, Palta P, Farh KH, Cuenca-Leon E, Furlotte N, Kurth T, Ligthart L, Terwindt GM, Freilinger T, Ran C, Gordon SD, Borck G, Adams HHH, Lehtimäki T, Wedenoja J, Buring JE, Schürks M, Hrafnsdottir M, Hottenga JJ, Penninx B, Artto V, Kaunisto M, Vepsäläinen S, Martin NG, Montgomery GW, Kurki MI, Hämäläinen E, Huang H, Huang J, Sandor C, Webber C, Muller-Myhsok B, Schreiber S, Salomaa V, Loehrer E, Göbel H, Macaya A, Pozo-Rosich P, Hansen T, Werge T, Kaprio J, Metspalu A, Kubisch C, Ferrari MD, Belin AC, van den Maagdenberg AMJM, Zwart JA, Boomsma D, Eriksson N, Olesen J, Chasman DI, Nyholt DR, Avbersek A, Baum L, Berkovic S, Bradfield J, Buono R, Catarino CB, Cossette P, De Jonghe P, Depondt C, Dlugos D, Ferraro TN, French J, Hjalgrim H, Jamnadas-Khoda J, Kälviäinen R, Kunz WS, Lerche H, Leu C, Lindhout D, Lo W, Lowenstein D, McCormack M, Møller RS, Molloy A, Ng PW, Oliver K, Privitera M, Radtke R, Ruppert AK, Sander T, Schachter S, Schankin C, Scheffer I, Schoch S, Sisodiya SM, Smith P, Sperling M, Striano P, Surges R, Thomas GN, Visscher F, Whelan CD, Zara F, Heinzen EL, Marson A, Becker F, Stroink H, Zimprich F, Gasser T, Gibbs R, Heutink P, Martinez M, Morris HR, Sharma M, Ryten M, Mok KY, Pulit S, Bevan S, Holliday E, Attia J, Battey T, Boncoraglio G, Thijs V, Chen WM, Mitchell B, Rothwell P, Sharma P, Sudlow C, Vicente A, Markus H, Kourkoulis C, Pera J, Raffeld M, Silliman S, Boraska Perica V, Thornton LM, Huckins LM, William Rayner N, Lewis CM, Gratacos M, Rybakowski F, Keski-Rahkonen A, Raevuori A, Hudson JI, Reichborn-Kjennerud T, Monteleone P, Karwautz A, Mannik K, Baker JH, O'Toole JK, Trace SE, Davis OSP, Helder SG, Ehrlich S, Herpertz-Dahlmann B, Danner UN, van Elburg AA, Clementi M, Forzan M, Docampo E, Lissowska J, Hauser J, Tortorella A, Maj M, Gonidakis F, Tziouvas K, Papezova H, Yilmaz Z, Wagner G, Cohen-Woods S, Herms S, Julià A, Rabionet R, Dick DM, Ripatti S, Andreassen OA, Espeseth T, Lundervold AJ, Steen VM, Pinto D, Scherer SW, Aschauer H, Schosser A, Alfredsson L, Padyukov L, Halmi KA, Mitchell J, Strober M, Bergen AW, Kaye W, Szatkiewicz JP, Cormand B, Ramos-Quiroga JA, Sánchez-Mora C, Ribasés M, Casas M, Hervas A, Arranz MJ, Haavik J, Zayats T, Johansson S, Williams N, Dempfle A, Rothenberger A, Kuntsi J, Oades RD, Banaschewski T, Franke B, Buitelaar JK, Arias Vasquez A, Doyle AE, Reif A, Lesch KP, Freitag C, Rivero O, Palmason H, Romanos M, Langley K, Rietschel M, Witt SH, Dalsgaard S, Børglum AD, Waldman I, Wilmot B, Molly N, Bau CHD, Crosbie J, Schachar R, Loo SK, McGough JJ, Grevet EH, Medland SE, Robinson E, Weiss LA, Bacchelli E, Bailey A, Bal V, Battaglia A, Betancur C, Bolton P, Cantor R, Celestino-Soper P, Dawson G, De Rubeis S, Duque F, Green A, Klauck SM, Leboyer M, Levitt P, Maestrini E, Mane S, De-Luca DM, Parr J, Regan R, Reichenberg A, Sandin S, Vorstman J, Wassink T, Wijsman E, Cook E, Santangelo S, Delorme R, Rogé B, Magalhaes T, Arking D, Schulze TG, Thompson RC, Strohmaier J, Matthews K, Melle I, Morris D, Blackwood D, McIntosh A, Bergen SE, Schalling M, Jamain S, Maaser A, Fischer SB, Reinbold CS, Fullerton JM, Guzman-Parra J, Mayoral F, Schofield PR, Cichon S, Mühleisen TW, Degenhardt F, Schumacher J, Bauer M, Mitchell PB, Gershon ES, Rice J, Potash JB, Zandi PP, Craddock N, Ferrier IN, Alda M, Rouleau GA, Turecki G, Ophoff R, Pato C, Anjorin A, Stahl E, Leber M, Czerski PM, Cruceanu C, Jones IR, Posthuma D, Andlauer TFM, Forstner AJ, Streit F, Baune BT, Air T, Sinnamon G, Wray NR, MacIntyre DJ, Porteous D, Homuth G, Rivera M, Grove J, Middeldorp CM, Hickie I, Pergadia M, Mehta D, Smit JH, Jansen R, de Geus E, Dunn E, Li QS, Nauck M, Schoevers RA, Beekman AT, Knowles JA, Viktorin A, Arnold P, Barr CL, Bedoya-Berrio G, Bienvenu OJ, Brentani H, Burton C, Camarena B, Cappi C, Cath D, Cavallini M, Cusi D, Darrow S, Denys D, Derks EM, Dietrich A, Fernandez T, Figee M, Freimer N, Gerber G, Grados M, Greenberg E, Hanna GL, Hartmann A, Hirschtritt ME, Hoekstra PJ, Huang A, Huyser C, Illmann C, Jenike M, Kuperman S, Leventhal B, Lochner C, Lyon GJ, Macciardi F, Madruga-Garrido M, Malaty IA, Maras A, McGrath L, Miguel EC, Mir P, Nestadt G, Nicolini H, Okun MS, Pakstis A, Paschou P, Piacentini J, Pittenger C, Plessen K, Ramensky V, Ramos EM, Reus V, Richter MA, Riddle MA, Robertson MM, Roessner V, Rosário M, Samuels JF, Sandor P, Stein DJ, Tsetsos F, Van Nieuwerburgh F, Weatherall S, Wendland JR, Wolanczyk T, Worbe Y, Zai G, Goes FS, McLaughlin N, Nestadt PS, Grabe HJ, Depienne C, Konkashbaev A, Lanzagorta N, Valencia-Duarte A, Bramon E, Buccola N, Cahn W, Cairns M, Chong SA, Cohen D, Crespo-Facorro B, Crowley J, Davidson M, DeLisi L, Dinan T, Donohoe G, Drapeau E, Duan J, Haan L, Hougaard D, Karachanak-Yankova S, Khrunin A, Klovins J, Kučinskas V, Lee Chee Keong J, Limborska S, Loughland C, Lönnqvist J, Maher B, Mattheisen M, McDonald C, Murphy KC, Nenadic I, van Os J, Pantelis C, Pato M, Petryshen T, Quested D, Roussos P, Sanders AR, Schall U, Schwab SG, Sim K, So HC, Stögmann E, Subramaniam M, Toncheva D, Waddington J, Walters J, Weiser M, Cheng W, Cloninger R, Curtis D, Gejman PV, Henskens F, Mattingsdal M, Oh SY, Scott R, Webb B, Breen G, Churchhouse C, Bulik CM, Daly M, Dichgans M, Faraone SV, Guerreiro R, Holmans P, Kendler KS, Koeleman B, Mathews CA, Price A, Scharf J, Sklar P, Williams J, Wood NW, Cotsapas C, Palotie A, Smoller JW, Sullivan P, Rosand J, Corvin A, Neale BM.

Science. 2018 Jun 22;360(6395). PUBMED: 29930110 DOI: 10.1126/science.aap8757. 

Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families

Gormley P, Kurki MI, Hiekkala ME, Veerapen K, Häppölä P, Mitchell AA, Lal D, Palta P, Surakka I, Kaunisto MA, Hämäläinen E, Vepsäläinen S, Havanka H, Harno H, Ilmavirta M, Nissilä M, Säkö E, Sumelahti ML, Liukkonen J, Sillanpää M, Metsähonkala L, Koskinen S, Lehtimäki T, Raitakari O, Männikkö M, Ran C, Belin AC, Jousilahti P, Anttila V, Salomaa V, Artto V, Färkkilä M; 23andMe Research Team; International Headache Genetics Consortium (IHGC), Runz H, Daly MJ, Neale BM, Ripatti S, Kallela M, Wessman M, Palotie A.

Neuron. 2018 May 16;98(4):743-753.e4. PUBMED: 29731251 DOI: 10.1016/j.neuron.2018.04.014. [Epub 2018 May 3]

Shared genetic risk between migraine and coronary artery disease: A genome-wide analysis of common variants

Winsvold BS, Bettella F, Witoelar A, Anttila V, Gormley P, Kurth T, Terwindt GM, Freilinger TM, Frei O, Shadrin A, Wang Y, Dale AM, van den Maagdenberg AMJM, Chasman DI, Nyholt DR, Palotie A, Andreassen OA, Zwart JA; International Headache Genetics Consortium.

PLoS One. 2017 Sep 28;12(9):e0185663 PUBMED: 28957430  DOI: 10.1371/journal.pone.0185663. eCollection 2017

Serum calcium and risk of migraine: a Mendelian randomization study

Yin P, Anttila V, Siewert KM, Palotie A, Davey Smith G, Voight BF.

Hum Mol Genet. 2017 Feb 15;26(4):820-828 PUBMED: 28025330  DOI: 10.1093/hmg/ddw416

Epigenetic DNA methylation changes associated with headache chronification: A retrospective case-control study

Winsvold BS, Palta P, Eising E, Page CM; International Headache Genetics Consortium., van den Maagdenberg AM, Palotie A, Zwart JA.

Cephalalgia 2017 Jan 1:333102417690111. PUBMED: 28103696  DOI: 10.1177/0333102417690111 [Epub ahead of print]

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

Gormley P, Anttila V, Winsvold BS, Palta P, Esko T, Pers TH, Farh KH, Cuenca-Leon E, Muona M, Furlotte NA, Kurth T, Ingason A, McMahon G, Ligthart L, Terwindt GM, Kallela M, Freilinger TM, Ran C, Gordon SG, Stam AH, Steinberg S, Borck G, Koiranen M, Quaye L, Adams HH, Lehtimäki T, Sarin AP, Wedenoja J, Hinds DA, Buring JE, Schürks M, Ridker PM, Hrafnsdottir MG, Stefansson H, Ring SM, Hottenga JJ, Penninx BW, Färkkilä M, Artto V, Kaunisto M, Vepsäläinen S, Malik R, Heath AC, Madden PA, Martin NG, Montgomery GW, Kurki MI, Kals M, Mägi R, Pärn K, Hämäläinen E, Huang H, Byrnes AE, Franke L, Huang J, Stergiakouli E, Lee PH, Sandor C, Webber C, Cader Z, Muller-Myhsok B, Schreiber S, Meitinger T, Eriksson JG, Salomaa V, Heikkilä K, Loehrer E, Uitterlinden AG, Hofman A, van Duijn CM, Cherkas L, Pedersen LM, Stubhaug A, Nielsen CS, Männikkö M, Mihailov E, Milani L, Göbel H, Esserlind AL, Christensen AF, Hansen TF, Werge T; International Headache Genetics Consortium, Kaprio J, Aromaa AJ, Raitakari O, Ikram MA, Spector T, Järvelin MR, Metspalu A, Kubisch C, Strachan DP, Ferrari MD, Belin AC, Dichgans M, Wessman M, van den Maagdenberg AM, Zwart JA, Boomsma DI, Smith GD, Stefansson K, Eriksson N, Daly MJ, Neale BM, Olesen J, Chasman DI, Nyholt DR, Palotie A.

Nature Genetics 2016 Aug;48(8):856-66. PUBMED: 27322543 DOI: 10.1038/ng.3598 Epub 2016 Jun 20.

Gene-based pleiotropy across migraine with aura and migraine without aura patient groups

Zhao H, Eising E, de Vries B, Vijfhuizen LS; International Headache Genetics Consortium, Anttila V, Winsvold BS,Kurth T, Stefansson H, Kallela M, Malik R, Stam AH, Ikram MA, Ligthart L, Freilinger T, Alexander M, Müller-Myhsok B, Schreiber S, Meitinger T, Aromas A, Eriksson JG, Boomsma DI, van Duijn CM, Zwart JA, Quaye L, Kubisch C, Dichgans M, Wessman M, Stefansson K, Chasman DI, Palotie A, Martin NG, Montgomery GW, Ferrari MD, Terwindt GM, van den Maagdenberg AM, Nyholt DR.

Cephalalgia 2016 Jun;36(7):648-57. PUBMED: 26660531 DOI: 10.1177/0333102415591497 Epub 2015 Dec 8.

Involvement of astrocyte and oligodendrocyte gene sets in migraine

Eising E, de Leeuw C, Min JL, Anttila V, Verheijen MH, Terwindt GM, Dichgans M, Freilinger T, Kubisch C; International Headache Genetics Consortium, Ferrari MD, Smit AB, de Vries B, Palotie A, van den Maagdenberg AM, Posthuma D.

Cephalalgia 2016 Jun;36(7):640-7. PUBMED: 26646788 DOI: 10.1177/0333102415618614 Epub 2015 Dec 7. 

The influence of genetic constitution on migraine drug responses

Christensen AF, Esserlind AL, Werge T, Stefánsson H, Stefánsson K, Olesen J.

Cephalalgia 2016 Jun;36(7):624-39. PUBMED: 26502740 DOI: 10.1177/0333102415610874 Epub 2015 Oct 26. 

Systematic re-evaluation of genes from candidate gene association studies in migraine using a large genome-wide association data set

de Vries B, Anttila V, Freilinger T, Wessman M, Kaunisto MA, Kallela M, Artto V, Vijfhuizen LS, Göbel H, Dichgans M, Kubisch C, Ferrari MD, Palotie A, Terwindt GM, van den Maagdenberg AM; on behalf of the International Headache Genetics Consortium.

Cephalalgia 2016 Jun;36(7):604-14. PUBMED: 25633374 DOI: 10.1177/0333102414566820 Epub 2015 Jan 29.

Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology: a GWAS-based study using the Allen Human Brain Atlas

Eising E, Huisman SM, Mahfouz A, Vijfhuizen LS, Anttila V, Winsvold BS, Kurth T, Ikram MA, Freilinger T, Kaprio J, Boomsma DI, van Duijn CM, Järvelin MR, Zwart JA, Quaye L, Strachan DP, Kubisch C, Dichgans M, Davey Smith G, Stefansson K, Palotie A, Chasman DI, Ferrari MD,Terwindt GM, de Vries B, Nyholt DR, Lelieveldt BP, van den Maagdenberg AM, Reinders MJ.

Human Genetics 2016 Apr;135(4):425-39. PUBMED: 26899160 DOI: 10.1007/s00439-016-1638-x Epub 2016 Feb 22.

Calcitonin gene-related peptide induced migraine attacks in patients with and without familial aggregation of migraine

Guo S, Christensen AF, Liu ML, Janjooa BN, Olesen J, Ashina M.

Cephalalgia 2016 Mar 18. PUBMED: 26994300  DOI: 10.1177/0333102416639512 [Epub ahead of print]

Genetic Markers of Human Evolution Are Enriched in Schizophrenia

Srinivasan S, Bettella F, Mattingsdal M, Wang Y, Witoelar A, Schork AJ, Thompson WK, Zuber V; Schizophrenia Working Group of the Psychiatric Genomics Consortium, The International Headache Genetics Consortium, Winsvold BS, Zwart JA, Collier DA, Desikan RS, Melle I, Werge T, Dale AM, Djurovic S, Andreassen OA.

Biological Psychiatry 2015 Oct 21. PUBMED: 26681495 DOI: 10.1016/j.biopsych.2015.10.009 [Epub ahead of print]

Genetic analysis for a shared biological basis between migraine and coronary artery disease

Winsvold BS, Nelson CP, Malik R, Gormley P, Anttila V, Vander Heiden J, Elliott KS, Jacobsen LM, Palta P, Amin N, de Vries B, Hämäläinen E, Freilinger T, Ikram MA, Kessler T, Koiranen M, Ligthart L, McMahon G, Pedersen LM, Willenborg C, Won HH, Olesen J, Artto V, Assimes TL, Blankenberg S, Boomsma DI, Cherkas L, Davey Smith G, Epstein SE, Erdmann J, Ferrari MD, Göbel H, Hall AS, Jarvelin MR, Kallela M, Kaprio J,Kathiresan S, Lehtimäki T, McPherson R, März W, Nyholt DR, O'Donnell CJ, Quaye L, Rader DJ, Raitakari O, Roberts R, Schunkert H, Schürks M, Stewart AF, Terwindt GM, Thorsteinsdottir U, van den Maagdenberg AM, van Duijn C, Wessman M, Kurth T, Kubisch C, Dichgans M, Chasman DI, Cotsapas C, Zwart JA, Samani NJ, Palotie A; CARDIoGRAM Consortium and the International Headache Genetics Consortium.

Neurology Genetics 2015 Jul 2;1(1):e10. PUBMED: 27066539 DOI: 10.1212/NXG.0000000000000010 eCollection 2015.

In silico phenotyping via co-training for improved phenotype prediction from genotype

Roqueiro D, Witteveen MJ, Anttila V, Terwindt GM, van den Maagdenberg AM, Borgwardt K.

Bioinformatics 2015 Jun 15;31(12):i303-10. PUBMED: 26072497 DOI: 10.1093/bioinformatics/btv254 

Shared genetic basis for migraine and ischemic stroke: A genome-wide analysis of common variants

Malik R, Freilinger T, Winsvold BS, Anttila V, Vander Heiden J, Traylor M, de Vries B, Holliday EG, Terwindt GM, Sturm J, Bis JC, Hopewell JC, Ferrari MD, Rannikmae K, Wessman M, Kallela M, Kubisch C, Fornage M, Meschia JF, Lehtimäki T, Sudlow C, Clarke R, Chasman DI, Mitchell BD, Maguire J, Kaprio J, Farrall M, Raitakari OT, Kurth T, Ikram MA, Reiner AP, Longstreth WT Jr, Rothwell PM, Strachan DP, Sharma P, Seshadri S, Quaye L, Cherkas L, Schürks M, Rosand J, Ligthart L, Boncoraglio GB, Davey Smith G, van Duijn CM, Stefansson K, Worrall BB, Nyholt DR, Markus HS, van den Maagdenberg AM, Cotsapas C, Zwart JA, Palotie A; International Headache Genetics Consortium, Dichgans M; METASTROKE Collaboration of the International Stroke Genetics Consortium.

Neurology 2015 May 26;84(21):2132-45. PUBMED: 25934857 DOI: 10.1212/WNL.0000000000001606 

Concordance of genetic risk across migraine subgroups: Impact on current and futuregenetic association studies

Nyholt DR; for the International Headache Genetics Consortium:, Anttila V, Winsvold BS, Kurth T, Stefansson H,Kallela M, Malik R, Vries BD, Terwindt GM, Ikram MA, Stam AH, Ligthart L, Freilinger T, Alexander M, Muller-Myhsok B, Schreiber S, Meitinger T, Aromaa A, Eriksson JG, Kaprio J, Boomsma DI, van Duijn C, Raitakari O, Järvelin MR, Zwart JA, Quaye L, Strachan DP, Kubisch C, Ferrari MD, van den Maagdenberg AM, Dichgans M, Wessman M, Smith GD, Stefansson K, Chasman DI, Palotie A.

Cephalalgia 2015 May;35(6):489-99. PUBMED: 25179292 DOI: 10.1177/0333102414547784

Candidate-gene association study searching for genetic factors involved in migraine chronification

Louter M, Fernandez-Morales J, de Vries B, Winsvold B, Anttila V, Fernandez-Cadenas I, Vila-Pueyo M, Sintas C, van Duijn C, Cormand B, Alvarez-Sabin J, Montaner J, Ferrari M, van den Maagdenberg A, Palotie A, Zwart J, Macaya A, Terwindt G, Pozo-Rosich P.

Cephalalgia 2015 May;35(6):500-7. PUBMED: 25169732 DOI: 10.1177/0333102414547141 

Selectivity in genetic association with sub-classified migraine in women

Chasman DI, Anttila V, Buring JE, Ridker PM, Schürks M, Kurth T; International Headache Genetics Consortium.

PLoS Genetics 2014;May 22;10(5) PUBMED: 24852292 DOI: 10.1371/journal.pgen.1004366 eCollection 2014.

Erratum in: PLoS Genetics 2015 Jun 15;11(6):e1005330. PUBMED: 26075714 DOI: 10.1371/journal.pgen.1005330 eCollection 2015.

Genome-wide meta-analysis identifies new susceptibility loci for migraine

Anttila V, Winsvold BS, Gormley P, Kurth T, Bettella F, McMahon G, Kallela M, Malik R, de Vries B, Terwindt G, Medland SE, Todt U, McArdle WL, Quaye L,Koiranen M, Ikram MA, Lehtimäki T, Stam AH, Ligthart L, Wedenoja J, Dunham I, Neale BM, Palta P, Hamalainen E, Schürks M, Rose LM, Buring JE, Ridker PM,Steinberg S, Stefansson H, Jakobsson F, Lawlor DA, Evans DM, Ring SM, Färkkilä M, Artto V, Kaunisto MA, Freilinger T, Schoenen J, Frants RR, Pelzer N,Weller CM, Zielman R, Heath AC, Madden PA, Montgomery GW, Martin NG, Borck G, Göbel H, Heinze A, Heinze-Kuhn K, Williams FM, Hartikainen AL, Pouta A,van den Ende J, Uitterlinden AG, Hofman A, Amin N, Hottenga JJ, Vink JM, Heikkilä K, Alexander M, Muller-Myhsok B, Schreiber S, Meitinger T, Wichmann HE,Aromaa A, Eriksson JG, Traynor BJ, Trabzuni D, Rossin E, Lage K, Jacobs SB, Gibbs JR, Birney E, Kaprio J, Penninx BW, Boomsma DI, van Duijn C, Raitakari O, Jarvelin MR, Zwart JA, Cherkas L, Strachan DP, Kubisch C, Ferrari MD, van den Maagdenberg AM, Dichgans M, Wessman M, Smith GD, Stefansson K, Daly MJ, Nyholt DR, Chasman DI, Palotie A; North American Brain Expression Consortium; UK Brain Expression Consortium; International Headache Genetics Consortium.

Nature Genetics 2013;45;8;912-7 PUBMED: 23793025 DOI: 10.1038/ng.2676

Genome-wide association analysis identifies susceptibility loci for migraine without aura

Freilinger T, Anttila V, de Vries B, Malik R, Kallela M, Terwindt GM, Pozo-Rosich P, Winsvold B, Nyholt DR, van Oosterhout WP, Artto V, Todt U, Hämäläinen E, Fernández-Morales J, Louter MA, Kaunisto MA, Schoenen J,Raitakari O, Lehtimäki T, Vila-Pueyo M, Göbel H, Wichmann E, Sintas C,Uitterlinden AG, Hofman A, Rivadeneira F, Heinze A, Tronvik E, van Duijn CM, Kaprio J, Cormand B, Wessman M, Frants RR, Meitinger T, Müller-Myhsok B, Zwart JA, Färkkilä M, Macaya A, Ferrari MD, Kubisch C, Palotie A, Dichgans M,van den Maagdenberg AM and International Headache Genetics Consortium.

Nature Genetics 2012;44;7;777-82 PUBMED: 22683712 DOI: 10.1038/ng.2307

Genome-wide association study reveals three susceptibility loci for common migraine in the general population

Chasman DI, Schürks M, Anttila V, de Vries B, Schminke U, Launer LJ, Terwindt GM, van den Maagdenberg AM, Fendrich K, Völzke H, Ernst F, Griffiths LR, Buring JE, Kallela M, Freilinger T, Kubisch C, Ridker PM, Palotie A, Ferrari MD, Hoffmann W, Zee RY and Kurth T.

Nature Genetics 2011;43;7;695-8 PUBMED: 21666692 DOI: 10.1038/ng.856

Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1

Anttila V, Stefansson H, Kallela M, Todt U, Terwindt GM, Calafato MS, Nyholt DR, Dimas AS, Freilinger T, Müller-Myhsok B, Artto V, Inouye M, Alakurtti K, Kaunisto MA, Hämäläinen E, de Vries B, Stam AH, Weller CM, Heinze A, Heinze-Kuhn K, Goebel I, Borck G, Göbel H, Steinberg S, Wolf C, Björnsson A,Gudmundsson G, Kirchmann M, Hauge A, Werge T, Schoenen J, Eriksson JG,Hagen K, Stovner L, Wichmann HE, Meitinger T, Alexander M, Moebus S,Schreiber S, Aulchenko YS, Breteler MM, Uitterlinden AG, Hofman A, van Duijn CM, Tikka-Kleemola P, Vepsäläinen S, Lucae S, Tozzi F, Muglia P, Barrett J, Kaprio J, Färkkilä M, Peltonen L, Stefansson K, Zwart JA, Ferrari MD, Olesen J,Daly M, Wessman M, van den Maagdenberg AM, Dichgans M, Kubisch C,Dermitzakis ET, Frants RR, Palotie A and International Headache Genetics Consortium.

Nature Genetics 2010;42;10;869-73 PUBMED: 20802479 DOI: 10.1038/ng.652

A high-density association screen of 155 ion transport genes for involvement with common migraine

Nyholt DR, LaForge KS, Kallela M, Alakurtti K, Anttila V, Färkkilä M, Hämäläinen E, Kaprio J, Kaunisto MA, Heath AC, Montgomery GW, Göbel H,Todt U, Ferrari MD, Launer LJ, Frants RR, Terwindt GM, de Vries B, Verschuren WM, Brand J, Freilinger T, Pfaffenrath V, Straube A, Ballinger DG, Zhan Y, Daly MJ, Cox DR, Dichgans M, van den Maagdenberg AM, Kubisch C, Martin NG,Wessman M, Peltonen L and Palotie A.

Human Molecular Genetics 2008;17;21;3318-31 PUBMED: 18676988 DOI: 10.1093/hmg/ddn227