Datasets & Cohorts

Published GWAS Datasets

Cohorts (Population-based)

• ALSPAC (The Avon Longitudinal Study of Parents and Children) 

• Australian Twin cohort

• B58C (British 1958 Birth Cohort)

• ERF (The Erasmus Rucphen Family Study)

• FinnTwin (Finnish Twin Cohort)

• HUNT (The Nord-Trøndelag Health Study)

• NTR (the Netherlands Twin Registry)

• NESDA (the Netherlands Study of Depression and Anxiety)

• NFBC (Northern Finland Birth Cohort)

• The Rotterdam Study

• Twins UK

• The Women’s Genome Health Study (WGHS)

• 1000 Genomes

GWAS Summary Statistics

Gormley et al. (2016) Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nat Genet. 2016 Aug;48(8):856-66. doi: 10.1038/ng.3598

Summary statistics for SNPs with P < 5e-8 are available for download:

• Any Migraine (59,674 cases vs 316,078 controls)  any_mig.gwama_.out_.isq75.nstud12.clean_.p1e-5_3.txt (1 MB) 

• MA Only - migraine with aura (6,332 cases vs 144,883 controls) MA.gwama_.out_.isq75.nstud6_.clean_.p1e-5_0.txt (69 KB)

• MO Only - migraine without aura (8,348 cases vs 139,622 controls) MO.gwama_.out_.isq75.nstud6_.clean_.p1e-5_0.txt (173 KB)

• For data format details, refer to the GWAMA tutorial (under OUTPUT FILES).

Academic access to the Gormley et al. (2016) [PMID: 27322543] genome-wide summary statistics, excluding 23andMe, is provided via a secondary analysis proposal to the IHGC briefly detailing a specific research question. If you wish to apply for access, please download the Migraine_analysis_proposal_form.docx—referring to the IHGC publication policy and principles for data access—and return the completed proposal form to Prof. Dale R. Nyholt via email to d.nyholt@qut.edu.au.

The 23andMe GWAS summary statistics will be made available through 23andMe to qualified researchers under an agreement with 23andMe that protects the privacy of the 23andMe participants. Please visit https://research.23andme.com/dataset-access/ for more information and to apply to access the data.

Hautakangas et al. (2022) Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles. Nat Genet. 2022 Feb;54(2):152-160. doi: 10.1038/s41588-021-00990-0

Summary statistics for 8,117 SNPs with P < 5e-8 are available for download:

• migraine_ihgc2021_gws_gwama_0.txt (1.1 MB) and accompanying

• README_migraine_ihgc2021_gws_gwama.txt (2 KB).

• For data format details, refer to the GWAMA tutorial (under OUTPUT FILES).

Academic access to the Hautakangas et al. (2022) [PMID: 35115687] genome-wide summary statistics, excluding 23andMe, is provided via a secondary analysis proposal to the IHGC briefly detailing a specific research question. If you wish to apply for access, please download the Migraine_analysis_proposal_form.docx—referring to the IHGC publication policy and principles for data access—and return the completed proposal form to Prof. Dale R. Nyholt via email to d.nyholt@qut.edu.au.

The 23andMe GWAS summary statistics will be made available through 23andMe to qualified researchers under an agreement with 23andMe that protects the privacy of the 23andMe participants. Please visit https://research.23andme.com/dataset-access/ for more information and to apply to access the data.

Please note that there are no genome-wide GWASS for the subtypes migraine with aura (MA) and migraine without (MO) in Hautakangas et al. (2022)—this paper only had MA and MO association results for the 123 lead variants, and this data is reported in Supplementary Table 3b and 3c (respectively) of the paper.